Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Srikanta Dash0
David H. Coy0
Jane A McKeating0
Robert F. Garry0
Date of Patent
August 26, 2008
Patent Application Number
10532480
Date Filed
November 7, 2003
Patent Primary Examiner
Patent abstract
The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which employ peptides or peptide derivatives to inhibit Flavivirus:cell fusion. The present invention is based in part on the discovery that E1 envelope glycoprotein of hepaciviruses and E2 envelope glycoprotein of pestivirus have previously undescribed structures, truncated class II fusion proteins. The present invention provides peptides and methods of treatment and prophylaxis of diseases induced by Flaviviruses.
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