US Patent 7414144 Preparation of 2S,3S-

Patent 7414144 was granted and assigned to Aerojet on August, 2008 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

Aerojet

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7414144

Date of Patent

August 19, 2008

Patent Application Number

11052934

Date Filed

February 7, 2005

Patent Primary Examiner

‌

Peter O'Sullivan

Patent abstract

The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.