US Patent 7410757 Method of screening disease depressant gene

The present invention provides methods for screening and testing disorder suppressor genes and disorder suppressor polypeptides. By screening the cDNA expression library incorporated with nucleic acids derived from an organism suffering from a disorder that accompanies cell death, genes having suppressive effects on the disorder symptoms were successfully cloned. Furthermore, suppressive effects of the nucleic acid and polypeptide encoded by the nucleic acid on the disorder have been also examined. Screening of nucleic acids or polypeptides derived from an organism suffering from a disorder that accompanies cell death enables the efficient isolation and selection of suppressor genes of the disorder.