US Patent 7402392 In vivo panning for ligands to radiation-induced molecules

Patent 7402392 was granted and assigned to Vanderbilt University on July, 2008 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors Activity

Is a

Patent

Patent attributes

Current Assignee

Vanderbilt University

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

74023920

Patent Inventor Names

Shimian Qu0

Dennis E. Hallahan0

Date of Patent

July 22, 2008

Patent Application Number

102590870

Date Filed

September 27, 2002

Patent Primary Examiner

‌

T. D. Wessendorf

Patent abstract

A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.