Patent 7399829 was granted and assigned to Xencor on July, 2008 by the United States Patent and Trademark Office.
The present invention relates to novel, soluble, recombinant variants RANKL (Receptor Activator of Nuclear Factor—κB Ligand) proteins, which may be expressed solubly in E. coli, variants that act as RANKL antagonists, and methods for generating the same.