Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ying Tang0
Jeffry D. Watkins0
Peter Brooks0
William D. Huse0
Daniel Broek0
Date of Patent
June 24, 2008
0Patent Application Number
100112500
Date Filed
December 6, 2001
0Patent Primary Examiner
Patent abstract
The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
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