A filtration system is provided with filter media operable to remove solids, particulate and colloidal matter from a process fluid. The filtration system may include one or more porous membranes which are anchored or secured on their periphery with a large open work area operable to remove selected components from the process fluid. The filter media may include an envelope formed from two membrane sheets with a spacer element disposed there between. A chamber or collection zone may be formed within the envelope to receive clarified fluid separated from the process fluid. Alternatively, the filter media may be multiple layers of spiral wound membranes or a roll of membranes.