US Patent 7348430 Production of opioid analgesics

Patent 7348430 was granted and assigned to Acura Pharmaceuticals on March, 2008 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

Acura Pharmaceuticals

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7348430

Date of Patent

March 25, 2008

Patent Application Number

11040235

Date Filed

January 21, 2005

Patent Primary Examiner

‌

Bernard Dentz

Patent abstract

The present invention includes a process for the manufacture of dihydrothebaine, dihydrocodeinone enol acetate, hydrocodone, and analogs thereof by reacting dihydrocodeine or analogs thereof with benzophenone in the presence of potassium tert-alkylate in a hydrocarbon solvent to generate a reaction mixture containing an enolate of the corresponding ketone, followed by addition of the reaction mixture to the electrophilic agent and isolation of the product.