US Patent 7335488 Fluorescent proteins

Patent 7335488 was granted and assigned to The Chinese University of Hong Kong Chorus on February, 2008 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Current Assignee

The Chinese University of Hong Kong Chorus

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

73354880

Date of Patent

February 26, 2008

Patent Application Number

104066180

Date Filed

April 2, 2003

Patent Primary Examiner

‌

Hope Robinson

Patent abstract

The present invention is directed to novel spontaneously fluorescent proteins having a unique chromophore formed from the amino acid sequence FR1R2R3F where R1 is Q or S; R2 is Y, W, F or H; and R3 is G, A or S (SEQ ID NO:34). The invention also encompasses the expression of nucleic acids that encode the proteins of the invention in a wide variety of engineered host cells, and the isolation of engineered proteins. In other embodiments, the invention comprises methods of use, generally including tagging a molecule or cell with the proteins of the invention by either chemical means or recombinant techniques.