Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ann M. Moriarty0
John C. Mathison0
Peter S. Tobias0
Richard J. Ulevitch0
Didier J. Leturcq0
Date of Patent
February 5, 2008
Patent Application Number
10236051
Date Filed
September 3, 2002
Patent Citations Received
Patent Primary Examiner
Patent abstract
This invention provides hybridoma cell lines producing monoclonal antibodies which inhibit CD14 mediated cell activation. Monoclonal antibodies produced by these cell lines also are provided. The antibodies are useful for the detection of the presence of cell surface and soluble CD14 in a sample. Chimeric and CDR grafted antibodies generated from the above monoclonal antibodies are further provided. Pharmaceutical compositions containing the above biological compositions are provided. These are useful to treat and prevent disorders with CD14 mediated cell activation, such as sepsis.
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