US Patent 7320890 Soluble steroidal peptides for nucleic acid delivery

Patent 7320890 was granted and assigned to University of Utah on January, 2008 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

University of Utah

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7320890

Date of Patent

January 22, 2008

Patent Application Number

11099999

Date Filed

April 5, 2005

Patent Citations Received

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US Patent 11873327 Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof

Patent Primary Examiner

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James Ketter

Patent abstract

Amphiphilic lipopeptide compositions for gene delivery are disclosed. An illustrative amphiphilic lipopeptide composition includes a human protamine 2 peptide conjugated to a hydrophobic moiety. Illustrative hydrophobic moieties include sterols, bile acids, and fatty acids. The amphiphilic lipopeptide composition is mixed with a nucleic acid such that the nucleic acid binds to the peptide portion of the lipopeptide. This mixture is placed in contact with mammalian cells to effect transfection of the cells with the nucleic acid. A method of making such amphiphilic lipopeptides is also described.