Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Lisa McConlogue0
Mark E. Gurney0
Date of Patent
December 18, 2007
0Patent Application Number
100828040
Date Filed
February 22, 2002
0Patent Primary Examiner
Patent abstract
The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for development and hence is an appropriate therapeutic target. The transgenic animals are useful in various screening assays including identifying inhibitors of other enzymes involved in processing of APP to Aβ and determining a toxicity profile of inhibitors of BACE-1.
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