US Patent 7303898 Defective sindbis viral vectors

Patent 7303898 was granted and assigned to New York University Press on December, 2007 by the United States Patent and Trademark Office.

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US Patent 12116412 Induction and enhancement of antitumor immunity involving virus vectors expressing multiple epitopes of tumor associated antigens and immune checkpoint inhibitors or proteins

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Patent Inventor Names

Alicia Hurtado0

Daniel Meruelo0

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Patent abstract

Disclosed herein are new defective Sindbis viral vectors made from wild type Ar-339 Sindbis virus, with differences in replicase and envelope proteins between JT vectors and consensus Sindbis virus sequences, and also between JT and Ar-339 vectors. Also disclosed are plasmids used for the production of the vectors, methods for producing the vectors, methods for treating mammals suffering from tumors and pharmaceutical formulations for use in the treatment methods.

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