Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
November 27, 2007
Patent Application Number
11212901
Date Filed
August 26, 2005
Patent Primary Examiner
Patent abstract
The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
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