A patient pull-up system is provided which enables a single operator to reposition a patient situated on a patient support, such as a bed, cart, gurney, or table, from a slumped position to a more upright position nearer the head of the patient support. The repositioning event is accomplished with minimal risk of injury or discomfort to the operator and patient. The patient pull-up system includes a translating device, a frame member, and a clamp adapted to grasp a portion of a sheet situated between a patient and a patient support.