Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Rivka Adar0
Oren Bogin0
Avner Yayon0
Date of Patent
October 30, 2007
Patent Application Number
10424955
Date Filed
April 29, 2003
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides active fibroblast growth factor variants demonstrating enhanced receptor subtype specificity. The preferred novel variants retain binding to FGF Receptor Type 3 (FGFR3) triggering intracellular downstream mechanisms leading to activation of a biological response. Methods of utilizing preferred FGF mutants in preparation of medicaments for the treatment of malignancies and skeletal disorders including osteoporosis and enhancing fracture healing and wound healing processes are provided.
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