Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Hiroaki Yamamoto0
Takanori Nakajima0
Date of Patent
October 16, 2007
Patent Application Number
10746796
Date Filed
December 23, 2003
Patent Primary Examiner
Patent abstract
The present invention provides mutant D-aminoacylases and use thereof. The mutant D-aminoacylases are hard to be inhibited by the substrate and, comprise the amino acid sequences of the D-aminoacylase derived from Alcaligenes denitrificans subsp. xylosoxydans MI-4 strain, wherein amino acid residues at specific sites have been modified. The mutants of the present invention have high reaction specificity as well as resistance to inhibition by the substrate. The present invention enables high-yield production of D-amino acids using higher concentrations of N-acyl-DL-amino acid as the substrate. The mutants of the present invention are useful in producing D-tryptophan in particular.
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