US Patent 7264969 Carrier system for specific artery wall gene delivery

Patent 7264969 was granted and assigned to University of Utah on September, 2007 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

University of Utah

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7264969

Date of Patent

September 4, 2007

Patent Application Number

10416381

Date Filed

November 9, 2001

Patent Primary Examiner

‌

Deborah Crouch

Patent abstract

An artery wall binding peptide (AWBP) based on the artery wall cell-binding domain of apolipoprotein B-100 was conjugated to a cationic backbone configured for forming a complex with a nucleic acid to produce a composition that enhances gene transfer to artery wall cells. An illustrative cationic backbone is poly(ethylene glycol)-grafted-poly(L-lysine) (PEG-g-PLL). Methods of making and using the composition for gene transfer are also described.