A biopsy device and method for operating the biopsy device are disclosed. The method of operating the biopsy device can include varying the translational speed of a cutter independently of the speed of a motor driving translation of the cutter. The method can also include providing close loop control of a fluid system, such as a vacuum system, associated with the biopsy device. The method can also include control of a cutter motor including comparing an actual motor current with a predetermined motor current.