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US Patent 7244864 Process for the preparation of N,N-substituted 5-amino-1,3-benzenedicarboxamides

Patent 7244864 was granted and assigned to Bracco (company) on July, 2007 by the United States Patent and Trademark Office.

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Patent abstract

The invention relates to a process for the preparation of a compound of formula (I), wherein R represents a 2,3-dihydroxy-1-propyl or a 1,3-dihydroxy-2-propyl radical, via direct amidation of a dialkyl ester of 5-amino-1,3-benzenedicarboxylic acid of formula (V), wherein R1 represents a straight or branched (C1-C4)-alkyl group, with at least the stoichiometric amount of an amine of formula H2NR.

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