Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jean Y. J. Wang0
Paolo Vigneri0
Date of Patent
July 3, 2007
Patent Application Number
10312918
Date Filed
June 29, 2001
Patent Primary Examiner
Patent abstract
The chimeric Bcr-Abl oncoprotein is the molecular hallmark of chronic myelogenous leukemia (CML). In the cytoplasm, the protein transduces a growth signal that is responsible for overexpansion of cells. In the nucleus, the protein induces apoptosis. The invention is a method of treating cancer/killing Bcr-Abl expressing cells by inducing the translocation of Bcr-Abl to the nucleus to activate the apoptotic pathway in cancer cells.
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