US Patent 7238505 Immobilized DNA polymerase

Patent 7238505 was granted and assigned to Ahram Biosystems on July, 2007 by the United States Patent and Trademark Office.

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Patent Inventor Names

Hyun Jin Hwang0

Jeong Hee Kim0

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Patent abstract

The present invention relates to a DNA polymerase immobilized by covalent bonding. More particularly, the present invention relates to an immobilized DNA polymerase whose activity is maximally preserved by masking the active site of the DNA polymerase and optimizing interaction of the masked molecule to the substrate material. In one embodiment, the average activity of the immobilized DNA polymerase is more than about 10% relative to that of the solution phase DNA polymerase. Further provided by the invention are methods and kits for performing polymerase chain reactions (PCR).

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Official Website

https://pdfpiw.uspto.gov/.piw?Docid=072385050

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