Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
May 8, 2007
Patent Application Number
10156669
Date Filed
May 23, 2002
Patent Primary Examiner
Patent abstract
The present invention provides a process for preparing a peptide of formula (I):Sub-[L]-[NH-A-C(O)]n+m—OH (I)comprising:(a) reacting an immobilized compound of formula (II):Sub-(L)-[NH-A-C(O)]n—OH (II) with an amino acid ester or peptide derivative of formula (III):H—[NH-A-C(O)]m—O(tBu) (III) in the presence of a coupling agent to yield a peptide compound of general formula (IV):Sub-[L]-[NH-A-C(O)]n+m—O(tBu); (IV)(b) removing the tBu (t-butyl) group to produce a solid-support bound carboxylic acid or peptide derivative of general formula (I);wherein n is a positive integer, e.g., 1-10, preferably 1-5; m is a positive integer.
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