A patient positioning assistance device is disclosed. The patient positioning assistance device is placed under the head of a patient in a supine position during endotracheal intubation of the patient. The device comprises a base and an inflatable chamber slidably coupled to the base to facilitate positioning of the chamber under the head of the patient and being operable to adjust a tilt position of the head of the patient to facilitate insertion and proper placement of a laryngoscope blade into the mouth of the patient.