US Patent 7211661 Trans-excision-splicing ribozyme and methods of use

Patent 7211661 was granted and assigned to University of Kentucky on May, 2007 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

University of Kentucky

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7211661

Date of Patent

May 1, 2007

Patent Application Number

10730261

Date Filed

December 9, 2003

Patent Primary Examiner

‌

James Schultz

Patent abstract

A group I intron-derived ribozyme which binds RNA in trans, excises an internal segment from within the RNA, and splices the remaining 5′ and 3′ ends of the RNA back together (the trans-excision-splicing reaction) is disclosed. The excised segment can be as long as 28 nucleotides, or more, and as little as one nucleotide. The ribozymes of the invention are easily modified to alter their sequence specificity. Such ribozymes represent a new and potentially powerful class of generally adaptable genetic therapeutics.