Patent 7211248 was granted and assigned to SONOGENE, LLC on May, 2007 by the United States Patent and Trademark Office.
A method for transfection of DNA or RNA encoding apo A1 into the liver to regulate lipid metabolism comprises injection of a solution containing the DNA or RNA gene into the liver in combination with gas microbubbles or microspheres and using ultrasound to induce the transfection of the DNA or RNA in the liver.