US Patent 7202340 No-modified hemoglobins and uses therefor

Patent 7202340 was granted and assigned to Duke University on April, 2007 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

Duke University

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7202340

Patent Inventor Names

Andrew J. Gow0

Jonathan S. Stamler0

Date of Patent

April 10, 2007

Patent Application Number

10638969

Date Filed

August 11, 2003

Patent Primary Examiner

‌

David Lukton

Patent abstract

Nitrosylhemoglobin can be produced by introducing gaseous NO into an aqueous solution of hemoglobin. It has been demonstrated that nitrosylhemoglobin in aqueous solution can be converted to SNO-hemoglobin upon introduction of oxygen to the solution, as is postulated to occur in the lungs. Nitrosylhemoglobin can be used in methods to produce the physiological effects of NO, for example, to reduce vasoconstriction and to inhibit platelet aggregation.