Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Zhaoyin Wang0
Lianhai Li0
Nicholas Lachance0
Robert N. Young0
Carl Berthelette0
Claude Dufresne0
Claudio Sturino0
Date of Patent
April 3, 2007
0Patent Application Number
105210750
Date Filed
July 24, 2003
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events
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