Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Adrienne Dubin0
Sean Brown0
Sandra Chaplan0
Edward Kaftan0
Date of Patent
March 27, 2007
0Patent Application Number
101217590
Date Filed
April 12, 2002
0Patent Primary Examiner
Patent abstract
The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Nav expression is either Nav1.3 in IMR-32 cells exposed to retinoic acid or Nav1.7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Nav1.3 and/or Nav1.7.
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