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US Patent 7192737 Methods and materials for increasing expression of recombinant polypeptides

Patent 7192737 was granted and assigned to XOMA on March, 2007 by the United States Patent and Trademark Office.

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Patent
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Patent attributes

Current Assignee
XOMA
XOMA
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
71927370
Patent Inventor Names
Arnold H. Horwitz0
Date of Patent
March 20, 2007
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Patent Application Number
104047240
Date Filed
March 31, 2003
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Patent Primary Examiner
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James Ketter
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Patent abstract

The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or transfecting host cells with expression vectors to increase transcription unit dosage and expression.

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