Patent 7183432 was granted and assigned to Iowa State University on February, 2007 by the United States Patent and Trademark Office.
A method of synthesizing diacetylenic amides is described. The key steps of the invention include the reaction of an aldehyde with the monoanion of a diacetylene and the reductive removal of a propargylic alcohol. The invention offers the first known method of synthesizing diacetylenic amides that are naturally isolated from Echinacea through a direct and flexible route.