Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Robert H. R. Feling0
Paul Jensen0
Tracy Mincer0
William Fenical0
Date of Patent
February 20, 2007
0Patent Application Number
106008540
Date Filed
June 20, 2003
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi.
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