Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Lakshman R. Sehgal0
Jonathan Wong0
Date of Patent
February 20, 2007
0Patent Application Number
107250130
Date Filed
December 2, 2003
0Patent Primary Examiner
Patent abstract
The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vitro using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.
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