Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Susan J. Sullivan0
Paul A. DiMilla0
Paul G. Gregory0
Date of Patent
January 30, 2007
0Patent Application Number
106076950
Date Filed
June 27, 2003
0Patent Primary Examiner
Patent abstract
The invention features a liver cell culture comprising hepatocytes that have increased detoxification enzyme activity when isolated from a liver of a donor that had been administered at least one induction agent prior isolation of hepatocyte cells. The induced hepatocytes are used in a bioreactor and cultured to produce hepatocyte cell products or metabolize toxins added to the culture. The bioreactor is, or is an integral part of, a liver assist device used to treat a patient in need of liver assist.
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