Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michael J. Coyne0
Dennis L. Kasper0
Katja G. Weinacht0
Laurie E. Comstock0
Arthur O. Tzianabos0
Date of Patent
January 23, 2007
0Patent Application Number
103883900
Date Filed
March 13, 2003
0Patent Primary Examiner
Patent abstract
The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
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