Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Gerald P. Murphy0
Alton L. Boynton0
Anil Sehgal0
Date of Patent
January 9, 2007
0Patent Application Number
093013800
Date Filed
April 27, 1999
0Patent Primary Examiner
Patent abstract
The present invention relates to the identification of a novel role of Nr-CAM in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of Nr-CAM in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for Nr-CAM. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of Nr-CAM gene expression or the inhibition of Nr-CAM activity in transformed cells reverses the transformed phenotype.
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