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US Patent 7138492 Method of treating dopaminergic and GABA-nergic disorders

Patent 7138492 was granted and assigned to Curis Limited on November, 2006 by the United States Patent and Trademark Office.

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Monica Wang0

Ping Jin0

Ningning Miao0

Kevin Pang0

Nagesh K. Mahanthappa0

Date of Patent

November 21, 2006

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Patent Application Number

094519390

Date Filed

December 1, 1999

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Patent Primary Examiner

Janet L. Andres

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Patent abstract

It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons. Interestingly, hedgehog not only promotes dopaminergic neuron survival, but also promotes the survival of midbrain GABA-immunoreactive (GABA-ir) neurons.

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