A laser beam irradiation device is equipped with a very strict safety arrangement, thereby assuring that a user can use it safely. A hand-held applicator has a face formed on its top, and a push button switch on its side. The face has a spherical lens press-fitted in its center hole, and the face has a hollow cylinder integrally connected to its circumference, encircling the spherical lens. The hand-held applicator is applied to one's skin by the hollow cylinder at its edge. The hollow cylinder has a cylindrical electrode embedded in and somewhat projecting forward. A heat sink is placed behind the spherical lens, and a semiconductor laser diode is press-fitted in the through hole, which is made in the center of the heat sink. A cooling fan is placed behind the heat sink.