Patent 7135055 was granted and assigned to Nanosphere on November, 2006 by the United States Patent and Trademark Office.
The present invention relates to composite core/shell nanoparticles and a two-step method for their preparation. The present invention further relates to biomolecule-core/shell nanoparticle conjugates and methods for their preparation. The invention also relates to methods of detection of biomolecules comprising the biomolecule or specific binding substance-core/shell nanoparticle conjugates.