US Patent 7122634 Modified factor VIII

Patent 7122634 was granted and assigned to Emory University on October, 2006 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors Activity

Is a

Patent

Patent attributes

Current Assignee

Emory University

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

71226340

Patent Inventor Names

John S. Lollar0

Date of Patent

October 17, 2006

Patent Application Number

109384140

Date Filed

September 10, 2004

Patent Primary Examiner

‌

Kathleen M. Kerr

Patent abstract

Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor VIII is disclosed in which the amino acid sequence is changed by a substitution at one or more of the specific loci. The modified factor VIII is not inhibited by inhibitory antibodies against the A2 or C2 domain epitopes. The modified factor VIII is useful for hemophiliacs, either to avoid or prevent the action of inhibitory antibodies.