Patent 7105341 was granted and assigned to Rigel Pharmaceuticals on September, 2006 by the United States Patent and Trademark Office.
The compositions relate to retroviral vectors encoding intein containing polypeptides which, when expressed in an eukaryotic cell, are capable of generating cyclic peptides. The retroviral vectors are used in methods for producing cyclic peptides and for identifying peptides capable of altering cellular phenotypes.