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US Patent 7019193 Treatments using transgenic goat produced antithrombin III

Patent 7019193 was granted and assigned to GTC BIOTHERAPEUTICS, INC. on March, 2006 by the United States Patent and Trademark Office.

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Patent attributes

Current Assignee

GTC BIOTHERAPEUTICS, INC.

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Harry M. Meade0

Edward S. Cole0

Paul Ditullio0

Date of Patent

March 28, 2006

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Patent Application Number

101886580

Date Filed

July 2, 2002

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Patent Primary Examiner

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Patent abstract

This invention relates to transgenically produced human Antithrombin III (tgATIII). The human ATIII produced by the transgenic process of the present invention has a monosaccharide composition which comprises N-acetylgalactosamine (GalNAc) along with fucose, N-acetylglucosamine, galactose, mannose, and N-acetylneuraminic acid/N-glycolyneuraminic acid. The monosaccharide composition differs with that of plasma derived ATIII (phATIII). It has been found that tgATIII has an increased clearance rate when compared to phATIII.

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