Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Tao Chen0
David Tirrell0
Jung Soo Kim0
Peter Cullis0
Peter Scherrer0
Phalgun Joshi0
Thomas Madden0
Yuehua He0
Date of Patent
January 17, 2006
0Patent Application Number
096741910
Date Filed
April 27, 1999
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make pH-sensitive liposomes which become unstable, permeable or fusogenic with certain pH changes. In addition, this invention generally describes methods for delivering therapeutic compounds and drugs to target cells by administering to a host the pH-sensitive liposomes of the present invention.
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