A water stopping and infiltration-proof structure for a lotion spray nozzle, which is accomplished by adopting a water-stopping flange that is integrated with the cover top and is expanded from the top of the straight shaft tube, together with female and mate threading that are moved outwards along with the spray nozzle's bottom rim and the integrated cover's rim. This will enable the water-stopping flange to wipe off water drops on the piston shaft surface, and prevent water on the integrated cover top from infiltrating into the shaft tube.