US Patent 6949585 Cyclooctanone derivatives and cyclodecanone derivative, and use thereof

The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is represented by the following general formula (I) [wherein A represents a cyclic group which may be substituted; the partial structure -DE- represents a group represented by —CH2CH2— or —CH═CH—; W represents a group represented by —CH2—, —CH2CH2—, —CH═CH— or —CH═; the partial structure >XY— represents a group represented by >CH—(CH2)n—, >C═CH—, >CH—CH2—CH(OH)—, >CH—CH2—C(═O)—, >CH—O— or >CH—O—CO—, provided that when W is —CH═, then XY— represents C—(CH2)p—; Z represents a divalent aliphatic hydrocarbon group; R1 and R2, which may be the same or different, each represents a hydrogen atom, or a hydroxyl, alkoxy or alkoxyalkoxy group; m is an integer of 0 or 1].