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US Patent 6936467 Targeted chromosomal genomic alterations with modified single stranded oligonucleotides

Patent 6936467 was granted and assigned to University of Delaware on August, 2005 by the United States Patent and Trademark Office.

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Patent

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Patent Applicant

Current Assignee

University of Delaware

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

69364670

Patent Inventor Names

Howard B. Gamper0

Eric B. Kmiec0

Michael C. Rice0

Date of Patent

August 30, 2005

Patent Application Number

098188750

Date Filed

March 27, 2001

Patent Primary Examiner

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Dave T Nguyen

Patent abstract

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base analogs.

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