Patent 12134777 was granted and assigned to VLP Therapeutics on November, 2024 by the United States Patent and Trademark Office.
Provided herein is a novel immunologically-active alphavirus replicon vector which comprises a nucleic acid encoding alphavirus nonstructural proteins nsp1-4 and a cytokine protein(s)/polypeptide(s), which is useful for the treatment of a cancer and/or an inflammatory disease.