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US Patent 12134632 On-column viral inactivation methods

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Glen Bolton0

Keith Selvitelli0

Date of Patent

November 5, 2024

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Patent Application Number

181536690

Date Filed

January 12, 2023

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Patent Citations

US Patent 11578098 On-column viral inactivation methods

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US Patent 8329182 Immunoglobulin chimeric monomer-dimer hybrids

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US Patent 10611794 On-column viral inactivation methods

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US Patent 6998253 Altered polypeptides with increased half-life

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US Patent 7083784 Molecules with extended half-lives, compositions and uses thereof

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US Patent 7317091 Optimized Fc variants

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US Patent 7404956 Immunoglobulin chimeric monomer-dimer hybrids

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Patent Primary Examiner

Monzer R Chorbaji

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CPC Code

0

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Patent abstract

The present invention is directed to a method of inactivating virus that is present during production of a polypeptide of interest. In particular, the present invention is directed to a method of on-column virus inactivation using a low pH and high salt wash solution that effectively inactivates viruses with minimum recovery loss of the polypeptide.

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