US Patent 12121281 Systems and methods for cryogenic treatment of headache

Methods and related systems treating headache and migraine. The method may include producing an injury to a nerve at an identified location of hypersensitivity; wherein the identified location is a location of nerve hypersensitivity. The identified location may be within the anterior or frontal aspect of a nasal cavity, corresponding to a location of the V1 branch of the trigeminal nerve. Producing an injury may comprise providing cryotherapy to the identified location. The cryotherapy is supplied by a chilled probe, a cryo-balloon, a nasal spray device, or a gel applicator.