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US Patent 12118414 BCL-2 proteins degraders for cancer treatment

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Contents

Is a
Patent
Patent
0

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
0
Patent Number
121184140
Patent Inventor Names
Daohong Zhou0
Peiyi Zhang0
Guangrong Zheng0
Sajid Khan0
Xuan Zhang0
Yonghan He0
Date of Patent
October 15, 2024
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Patent Application Number
169628160
Date Filed
January 22, 2019
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Patent Citations
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US Patent 8232273 Heterocyclic compounds and methods of use
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US Patent 8580794 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
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US Patent 8691184 Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same
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US Patent 8940737 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
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US Patent 9096625 BCL-2/BCL-XL inhibitors and therapeutic methods using the same
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US Patent 9345702 Methods of treatment using selective Bcl-2 inhibitors
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US Patent 9403856 Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same
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US Patent 10730862 Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an E3 ubiquitin ligase
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...
Patent Primary Examiner
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Raymond J. Henley, III
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CPC Code
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A61P 35/00
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A61K 31/496
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Patent abstract

The present disclosure provides compositions and methods for selectively killing cancer cells, wherein the composition comprises a compound of Formula (I). The selective killing of cancer cells occurs with an improved potency and safety profile compared to similar compounds. In particular, the compositions and methods of the invention show reduced platelet toxicity and retained or improved toxicity in cancer cells.

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